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Lgr4tm1.1(cre/ERT2)Npa
Targeted Allele Detail
Summary
Symbol: Lgr4tm1.1(cre/ERT2)Npa
Name: leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1.1, Novartis Pharma AG
MGI ID: MGI:5635820
Synonyms: Lgr4ki, Lgr4-mCherry-IRES-CreERT2
Gene: Lgr4  Location: Chr2:109747992-109844602 bp, + strand  Genetic Position: Chr2, 56.65 cM
Alliance: Lgr4tm1.1(cre/ERT2)Npa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212415
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Lgr4tm1.1(cre/ERT2)Npa expression driven by 1 gene
 
Mutation details: The targeting construct replaced exon 1 following the start codon and 287 bp of intron 1 with an mCherry reporter gene, IRES, inducible cre recombinase fusion (cre/ERT2), polyadenylation sequence and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Antibody testing and direct fluorescence failed to detect mCherry. In situ hybridization confirmed the absence of transcript expression in the intestin, skin and kidney. (J:212415)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lgr4 (mouse)
Summary of all recombinase alleles driven by Lgr4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 82 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr4 Mutation:  94 strains or lines available
References
Original:  J:212415 Kinzel B, et al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory