Tek<tm1.1(icre/Esr1*)Hrr> Targeted Allele Detail MGI Mouse (MGI:5635996)

Tek^{tm1.1(icre/Esr1*)Hrr}
Targeted Allele Detail

Summary

Symbol:	Tek^{tm1.1(icre/Esr1*)Hrr}
Name:	TEK receptor tyrosine kinase; targeted mutation 1.1, Hans-Reimer Rodewald
MGI ID:	MGI:5635996
Synonyms:	Tie2^MCM, Tie2^MCMdeltaNeo, Tie2^MeriCreMer
Gene:	Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
Alliance:	Tek^{tm1.1(icre/Esr1*)Hrr} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:219867
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Tek^{tm1.1(icre/Esr1*)Hrr} expression driven by 1 gene

Mutation details: The targeting cassette inserted into exon 1 upstream of the translation start site a rabbit HBB2 splice donor, intron and splice acceptor; an inducible improved cre fused to two modified Esr1 binding domains (icre/Esr1*); and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:219867)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tek Mutation:	92 strains or lines available

References

Original:	J:219867 Busch K, et al., Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Nature. 2015 Feb 26;518(7540):542-6
All:	6 reference(s)

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