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Col1a1tm1(tetO-GFP/RNAi:Pax5)Radi
Targeted Allele Detail
Summary
Symbol: Col1a1tm1(tetO-GFP/RNAi:Pax5)Radi
Name: collagen, type I, alpha 1; targeted mutation 1, Ross A Dickins
MGI ID: MGI:5636603
Synonyms: TRE-GFP-shPax5, TREtight-GFP-Pax5.437
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm1(tetO-GFP/RNAi:Pax5)Radi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211775
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Knockdown, RMCE-ready, Reporter)
Mutation:    Insertion
  Col1a1tm1(tetO-GFP/RNAi:Pax5)Radi involves 1 genes/genome features (Pax5) View all
 
Mutation details: RMCE on KH2 cells inserted a cassette that contains the tetracycline promoter and a GFP fusion with an Mir30e-based short hairpin sequence targeting Pax5 (Pax5.437) into the 3'UTR. (J:211775)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
Notes
This allele was generated with Col1a1tm13(neo/hygro*)Jae.
References
Original:  J:211775 Liu GJ, et al., Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia. Genes Dev. 2014 Jun 15;28(12):1337-50
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory