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Nfatc1tm1.1(cre/ERT2)Bzsh
Targeted Allele Detail
Summary
Symbol: Nfatc1tm1.1(cre/ERT2)Bzsh
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou
MGI ID: MGI:5637438
Synonyms: Nfatc1-CreER
Gene: Nfatc1  Location: Chr18:80649420-80756286 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Alliance: Nfatc1tm1.1(cre/ERT2)Bzsh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212075
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Nfatc1tm1.1(cre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: The coding sequence in exon 1 from the translation start site was replaced by an inducible cre recombinase gene (cre/ERT2). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the recombinase. Immunohistochemistry confirmed expression in the atrial and ventricular endocardium, but not sinus venosus, at E8.5 and E9.5. (J:212075)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nfatc1 (mouse)
Summary of all recombinase alleles driven by Nfatc1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:  49 strains or lines available
References
Original:  J:212075 Tian X, et al., Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 4;345(6192):90-4
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory