App<tm1.1Tcs> Targeted Allele Detail MGI Mouse (MGI:5637815)

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App^tm1.1Tcs
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	App^tm1.1Tcs
Name:	amyloid beta precursor protein; targeted mutation 1.1, Takaomi C Saido
MGI ID:	MGI:5637815
Synonyms:	App^NL
Gene:	App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	App^tm1.1Tcs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:212758
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Mutation
description

Allele Type:		Targeted (Humanized sequence)
Mutations:		Insertion, Nucleotide substitutions
		Mutation details: The sequence of exon 16 was humanized by the introduction of the Swedish mutations (p.KM670_671delinsNL) and a loxP site flanked neomycin resistance gene cassette was inserted in intron 16. Subsequent Cre-mediated recombination removed the neo cassette. (J:212758)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any App Mutation:	103 strains or lines available

References

Original:	J:212758 Saito T, et al., Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014 May;17(5):661-3
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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