App<tm3.1Tcs> Targeted Allele Detail MGI Mouse (MGI:5637817)

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App^tm3.1Tcs
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	App^tm3.1Tcs
Name:	amyloid beta precursor protein; targeted mutation 3.1, Takaomi C Saido
MGI ID:	MGI:5637817
Synonyms:	App^NL-G-F
Gene:	App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	App^tm3.1Tcs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:212758
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Mutation
description

Allele Type:		Targeted (Humanized sequence)
Mutations:		Insertion, Nucleotide substitutions
		Mutation details: The sequence of exon 16 was humanized by the introduction of the Swedish mutations (p.KM670_671delinsNL) and exon 17 by the introduction of the Arctic (p.E693G) and Beyreuther/Iberian (p.I716F) mutations. A loxP site flanked neomycin resistance gene cassette was inserted in intron 16 and subsequently removed through Cre-mediated recombination. (J:212758)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any App Mutation:	105 strains or lines available

References

Original:	J:212758 Saito T, et al., Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014 May;17(5):661-3
All:	153 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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