Casz1<tm2(cre/ERT2)Flc> Targeted Allele Detail MGI Mouse (MGI:5638932)

Casz1^{tm2(cre/ERT2)Flc}
Targeted Allele Detail

Summary

Symbol:	Casz1^{tm2(cre/ERT2)Flc}
Name:	castor zinc finger 1; targeted mutation 2, Frank Conlon
MGI ID:	MGI:5638932
Synonyms:	Casz1^CreERT2
Gene:	Casz1 Location: Chr4:148888886-149039346 bp, + strand Genetic Position: Chr4, 78.87 cM
Alliance:	Casz1^{tm2(cre/ERT2)Flc} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:221324
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Conditional ready, Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Casz1^{tm2(cre/ERT2)Flc} expression driven by 1 gene

Mutation details: An FRT-flanked inducible cre recombinase fusion gene (cre/ERT2) and neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 6. (J:221324)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Casz1 (mouse) Summary of all recombinase alleles driven by Casz1. Alliance mouse Casz1 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Casz1 Mutation:	345 strains or lines available

References

Original:	J:221324 Dorr KM, et al., Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development. Development. 2015 Jun 1;142(11):2037-47
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24