About   Help   FAQ
F13btm1Akic
Targeted Allele Detail
Summary
Symbol: F13btm1Akic
Name: coagulation factor XIII, beta subunit; targeted mutation 1, Akitada Ichinose
MGI ID: MGI:5645820
Gene: F13b  Location: Chr1:139429440-139451490 bp, + strand  Genetic Position: Chr1, 61.57 cM, cytoband F
Alliance: F13btm1Akic page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222849
Parent Cell Line:  EB3/5 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A genomic fragment including all of exons 1 and 2 was replaced with a neo cassette via homologous recombination. Northern and western blot analysis confirmed the absence of mRNA and protein expression in homozygous mice. Expression of F13a1 was greatly reduced compared to wild-type in homozygous mice. (J:222849)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F13b Mutation:  38 strains or lines available
Notes
ES cell line EB3/5 is a mutant E14TG2a line carrying one inactivated allele of Pou5f1. J:222849 does not specify whether the line of mice created carries the inactivated Pou5f1 allele.
References
Original:  J:222849 Souri M, et al., Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol. 2008 Jan;87(1):60-8
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory