b2b3121Clo Chemically induced Allele Detail MGI Mouse (MGI:5647996)

b2b3121Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b3121Clo
Name:	Mutant line 3121 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 3121 Cecilia Lo
MGI ID:	MGI:5647996
Synonyms:	ET
Gene:	b2b3121Clo Location: unknown
Alliance:	b2b3121Clo page

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See Wrn^b2b3121.1Clo and b2b3121.2Clo. (J:175213)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any b2b3121Clo Mutation:	0 strains or lines available

Notes

Summative Diagnosis:
Mutant Type 1:
Cardiovascular phenotypes: outflow anomaly comprising of bicuspic aortic or pulmonary valves.

Noncardiovascular phenotype: cleft palate, hypoplastic thymus, enlarged adrenal gland

Mutant Type 2:
Noncardiovascular phenotype: Hydrocephalus with possible cerebral arteriovenous malformation - (Vein of Galen)

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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