b2b3260Clo Chemically induced Allele Detail MGI Mouse (MGI:5648202)

b2b3260Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b3260Clo
Name:	Mutant line 3260 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 3260 Cecilia Lo
MGI ID:	MGI:5648202
Synonyms:	Po
Gene:	b2b3260Clo Location: unknown
Alliance:	b2b3260Clo page

Mutant 3260-006-2 (E16.5) exhibited an abnormal arrangement of the outflow tracts which was diagnosed as DORV (TOF Type), hypoplastic pulmonary, long right PDA, right aortic arch, and aberrant left subclavian artery by episcopic confocal histopathology

Show the 18 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See Tbc1d32^b2b3260.1Clo and b2b3260.2Clo. (J:175213)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any b2b3260Clo Mutation:	0 strains or lines available

Notes

Summative Diagnosis:
Mutant Type 1:
Cardiovascular phenotypes: Dysplastic semilunar valves, persistent truncus arteriosus (PTA), transposition of the great arteries (TGA)

Noncardiovascular phenotype: short snout, exencephaly, preaxial digit duplication, renal anomalies

Mutant Type 2:
Cardiovascular phenotypes: transposition of the great arteries, atrioventricular septal defect with cushion valves, myocardial noncompaction

Noncardiovascular phenotype: cleft palate, hypoplastic malformed thymus, kidney cysts

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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