Lats2<tm1.1Dupa> Targeted Allele Detail MGI Mouse (MGI:5648494)

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Lats2^tm1.1Dupa
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Lats2^tm1.1Dupa
Name:	large tumor suppressor 2; targeted mutation 1.1, Duojia Pan
MGI ID:	MGI:5648494
Synonyms:	Lats2^flox
Gene:	Lats2 Location: Chr14:57927119-57983669 bp, - strand Genetic Position: Chr14, 30.28 cM
Alliance:	Lats2^tm1.1Dupa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:223215
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Conditional ready)
Mutation:		Insertion
		Mutation details: A loxP site was placed in intron 4 and an FRT-neomycin-FRT-loxP cassette was introduced to intron 6. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:223215)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lats2 Mutation:	44 strains or lines available

References

Original:	J:223215 Chen Q, et al., Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015 Jun 15;29(12):1285-97
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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