Spata7<tm1Mrd> Targeted Allele Detail MGI Mouse (MGI:5660490)

Spata7^tm1Mrd
Targeted Allele Detail

Summary

Symbol:	Spata7^tm1Mrd
Name:	spermatogenesis associated 7; targeted mutation 1, Graeme Mardon
MGI ID:	MGI:5660490
Gene:	Spata7 Location: Chr12:98594416-98636074 bp, + strand Genetic Position: Chr12, 49.88 cM
Alliance:	Spata7^tm1Mrd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:216279
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic region encoding exons 1-10 was replaced with a neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of mRNA and protein expression in the retina. (J:216279)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Spata7 Mutation:	27 strains or lines available

References

Original:	J:216279 Eblimit A, et al., Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina. Hum Mol Genet. 2015 Mar 15;24(6):1584-601
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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