Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw> Targeted Allele Detail MGI Mouse (MGI:5661319)

Col1a1^{tm4(CAG-FGFR2_iIIIb*K660N)Kkw}
Targeted Allele Detail

Summary

Symbol:	Col1a1^{tm4(CAG-FGFR2_iIIIb*K660N)Kkw}
Name:	collagen, type I, alpha 1; targeted mutation 4, Kwok-Kin Wong
MGI ID:	MGI:5661319
Synonyms:	FGFR2^K660N
Gene:	Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1^{tm4(CAG-FGFR2_iIIIb*K660N)Kkw} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:214230
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Col1a1^{tm4(CAG-FGFR2_iIIIb*K660N)Kkw} expresses 1 gene

Mutation details: The chicken beta-actin (CAG) promoter, a loxP flanked STOP cassette, and human FGFR2 isoform IIIb cDNA with the kinase K660N domain activating mutation were inserted into the mouse collagen A1 locus. Upon cre-mediated recombination, the STOP cassette is excised promoting expression of the mutant FGFR2. (J:214230)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	163 strains or lines available

References

Original:	J:214230 Tchaicha JH, et al., Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res. 2014 Sep 1;74(17):4676-84
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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