Ddr2<tm1.1(cre/Esr1*)Rcow> Targeted Allele Detail MGI Mouse (MGI:5662369)

Ddr2^{tm1.1(cre/Esr1*)Rcow}
Targeted Allele Detail

Summary

Symbol:	Ddr2^{tm1.1(cre/Esr1*)Rcow}
Name:	discoidin domain receptor family, member 2; targeted mutation 1.1, Randy T Cowling
MGI ID:	MGI:5662369
Synonyms:	Ddr2^null
Gene:	Ddr2 Location: Chr1:169799876-169938331 bp, - strand Genetic Position: Chr1, 76.84 cM, cytoband H1-H5
Alliance:	Ddr2^{tm1.1(cre/Esr1*)Rcow} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:214642
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:

Targeted (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Ddr2^{tm1.1(cre/Esr1*)Rcow} expression driven by 1 gene

Mutation details: Part of exon 3 was replaced with two mutated mouse estrogen receptors that sequester cre to the cytoplasm, polyadenylation sequence and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in cultured cardiac fibroblasts. Only low expression of the modified cre product was detected. (J:214642)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ddr2 (mouse) Summary of all recombinase alleles driven by Ddr2. Alliance mouse Ddr2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ddr2 Mutation:	61 strains or lines available

References

Original:	J:214642 Cowling RT, et al., Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H773-81
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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