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Col10a1tm3.1(cre/ERT)Ksec
Targeted Allele Detail
Summary
Symbol: Col10a1tm3.1(cre/ERT)Ksec
Name: collagen, type X, alpha 1; targeted mutation 3.1, Kathryn S E Cheah
MGI ID: MGI:5662425
Synonyms: Col10a1-CreERt
Gene: Col10a1  Location: Chr10:34265977-34273081 bp, + strand  Genetic Position: Chr10, 18.85 cM, cytoband B1-B3
Alliance: Col10a1tm3.1(cre/ERT)Ksec page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213921
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Col10a1tm3.1(cre/ERT)Ksec expression driven by 1 gene
 
Mutation details: A tamoxifen-inducible cre recombinase fusion gene (cre/ERt) and an FRT-flanked neomycin resistance cassette were inserted at the translation initiation site in exon 2. Flp-mediated recombination removed the selection cassette. (J:213921)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Col10a1 (mouse)
Summary of all recombinase alleles driven by Col10a1.
 

Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col10a1 Mutation:  28 strains or lines available
References
Original:  J:213921 Yang L, et al., Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12097-102
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory