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Npy1rtm1Snby
Targeted Allele Detail
Summary
Symbol: Npy1rtm1Snby
Name: neuropeptide Y receptor Y1; targeted mutation 1, Amanda Sainsbury
MGI ID: MGI:5694958
Gene: Npy1r  Location: Chr8:67149844-67159444 bp, + strand  Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
Alliance: Npy1rtm1Snby page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225097
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation details: A hygromycin resistance cassette with a 5' loxP site was inserted downstream of the coding sequence. An additional loxP site was inserted upstream of the coding sequence. This allele was generated in ES cells containing Npy5rtm1Snby. (J:225097)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
cn1
Npy1rtm1Snby/Npy1rtm1Snby
Npy5rtm1Snby/Npy5rtm1Snby
involves: 129 * C57BL/6
 
Phenotypes:
Affected Systems
cn1
show or hide all annotated terms Sex:
adipose tissue
√
increased white adipose tissue amount
√
increased total body fat amount
√
behavior/neurological
√ √
decreased food intake
√ √
decreased compensatory feeding amount
√ √
decreased locomotor activity
√ √
hyperactivity
√ √
growth/size/body
√ √
growth/size/body region phenotype
N N
increased body weight
√ √
decreased susceptibility to weight gain
√
homeostasis/metabolism
√ √
homeostasis/metabolism phenotype
N N
increased circulating glucose level
√
increased energy expenditure
√
decreased respiratory quotient
√
increased respiratory quotient
√
impaired glucose tolerance
√
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npy1r Mutation:  25 strains or lines available
References
Original:  J:225097 Nguyen AD, et al., Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice. PLoS One. 2012;7(6):e40191
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory