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Lhx1tm1.1(icre)Rob
Targeted Allele Detail
Summary
Symbol: Lhx1tm1.1(icre)Rob
Name: LIM homeobox protein 1; targeted mutation 1.1, Elizabeth J Robertson
MGI ID: MGI:5698524
Synonyms: Lhx1iCreIRESLacZ, Lhx1iCre-LacZ, Lhx1iCre-nLacZ, Lhx1iCrenLacZ
Gene: Lhx1  Location: Chr11:84409110-84416361 bp, - strand  Genetic Position: Chr11, 51.31 cM
Alliance: Lhx1tm1.1(icre)Rob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226614
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Lhx1tm1.1(icre)Rob expression driven by 1 gene
 
Mutation details: The targeting construct inserted in frame with exon 1 an improved cre recombinase gene (icre), IRES, nuclear lacz reporter gene and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the recombinase gene. (J:226614)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lhx1 (mouse)
Summary of all recombinase alleles driven by Lhx1.
 

Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx1 Mutation:  22 strains or lines available
References
Original:  J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory