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Nfatc1tm1(cre)Bz
Targeted Allele Detail
Summary
Symbol: Nfatc1tm1(cre)Bz
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Bin Zhou
MGI ID: MGI:5699715
Synonyms: Nfatc1Cre-PGK
Gene: Nfatc1  Location: Chr18:80649420-80756286 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Alliance: Nfatc1tm1(cre)Bz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193198
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Nfatc1tm1(cre)Bz expression driven by 1 gene
 
Mutation details: A cassette containing an IRES-cre cDNA sequence and frt-flanked PGK-hygromycin selection marker was inserted into the 3' UTR (after the stop codon) of the Nfatc1 gene in R1 ES cells. Correctly targeted cells were selected and expanded, followed by blastocyst injection. (J:193198)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nfatc1 (mouse)
Summary of all recombinase alleles driven by Nfatc1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:  49 strains or lines available
References
Original:  J:193198 Wu B, et al., Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012 Nov 21;151(5):1083-96
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory