Tg(hs953-cre/ERT2,-GFP)526Jlr
Transgene Detail
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| Symbol: |
Tg(hs953-cre/ERT2,-GFP)526Jlr |
| Name: |
transgene insertion 526, John L R Rubenstein |
| MGI ID: |
MGI:5705353 |
| Synonyms: |
953-CreER-IRES-GFP |
| Transgene: |
Tg(hs953-cre/ERT2,-GFP)526Jlr Location: unknown
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| Alliance: |
Tg(hs953-cre/ERT2,-GFP)526Jlr page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase, Reporter) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(hs953-cre/ERT2,-GFP)526Jlr expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| human |
hs953 |
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Mutation details: This transgene contains the human enhancer element hs953, which is flanked on human Chr 2 by the Sp9 transcription factor (SP9) and corepressor interacting with RBPJ, 1 (CIR1) genes, followed by a minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus.
(J:94077)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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hs953
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015; |
| All: |
3 reference(s) |
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Analysis Tools
