Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO-URI1)Ndj
Name:	collagen, type I, alpha 1; targeted mutation 1, Nabil Djouder
MGI ID:	MGI:5706755
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO-URI1)Ndj page

Germline Transmission:	Earliest citation of germline transmission: J:217463
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-URI1)Ndj expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human URI1 (8725) Uri1  (MGI:1342294)   Mutation details: A construct containing an FRT site, tetO sequence, FLAG tagged human URI1 cDNA, and FRT site was inserted via RMCE in KH2 ES cells carrying the allele Col1a1tm13(neo/hygro*)Jae . (J:217463)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	163 strains or lines available

Original:	J:217463 Tummala KS, et al., Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell. 2014 Dec 8;26(6):826-39
All:	4 reference(s)