Ntrk3<tm3.1(cre/ERT2)Ddg> Targeted Allele Detail MGI Mouse (MGI:5707203)

Ntrk3^{tm3.1(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

Symbol:	Ntrk3^{tm3.1(cre/ERT2)Ddg}
Name:	neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 3.1, David D Ginty
MGI ID:	MGI:5707203
Synonyms:	TrkC^CreER
Gene:	Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
Alliance:	Ntrk3^{tm3.1(cre/ERT2)Ddg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:227979
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Ntrk3^{tm3.1(cre/ERT2)Ddg} expression driven by 1 gene

Mutation details: An indicible cre recombinase gene (cre/ERT2) and an FRT-flanked neomycin resistance cassette were inserted at the translation initiation site replacing the coding sequence in exon 1. Flp-mediated recombination removed the selection cassette. (J:227979)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk3 (mouse) Summary of all recombinase alleles driven by Ntrk3. Comparative matrix view of recombinase activities Alliance mouse Ntrk3 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:	65 strains or lines available

References

Original:	J:227979 Bai L, et al., Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking. Cell. 2015 Dec 17;163(7):1783-95
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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