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Crhtm2(icre)Ksak
Targeted Allele Detail
Summary
Symbol: Crhtm2(icre)Ksak
Name: corticotropin releasing hormone; targeted mutation 2, Kenji Sakimura
MGI ID: MGI:5707348
Synonyms: CRF-iCre, Crhtm2(icre)Itoi
Gene: Crh  Location: Chr3:19747565-19749560 bp, - strand  Genetic Position: Chr3, 5.75 cM
Alliance: Crhtm2(icre)Ksak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218341
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Crhtm2(icre)Ksak expression driven by 1 gene
 
Mutation details: A codon-optimized cre (icre) recombinase gene and neomycin resistance cassette were inserted downstream of the translation initiation site in exon 2. (J:218341)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Crh (mouse)
Summary of all recombinase alleles driven by Crh.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crh Mutation:  42 strains or lines available
References
Original:  J:218341 Itoi K, et al., Visualization of corticotropin-releasing factor neurons by fluorescent proteins in the mouse brain and characterization of labeled neurons in the paraventricular nucleus of the hypothalamus. Endocrinology. 2014 Oct;155(10):4054-60
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory