Zbtb46<tm3.1(cre)Mnz> Targeted Allele Detail MGI Mouse (MGI:5749231)

Zbtb46^{tm3.1(cre)Mnz}
Targeted Allele Detail

Summary

Symbol:	Zbtb46^{tm3.1(cre)Mnz}
Name:	zinc finger and BTB domain containing 46; targeted mutation 3.1, Michel C Nussenzweig
MGI ID:	MGI:5749231
Synonyms:	zDC^Cre
Gene:	Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
Alliance:	Zbtb46^{tm3.1(cre)Mnz} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:230708
Parent Cell Line:	CY2.4 (ES Cell)
Strain of Origin:	B6(Cg)-Tyr^c-2J

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Zbtb46^{tm3.1(cre)Mnz} expression driven by 1 gene

Mutation details: An FRT-flanked neomycin resistance cassette and an IRES-Cre element were introduced to exon 5, immediately after the stop codon. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:230708)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Zbtb46 (mouse) Summary of all recombinase alleles driven by Zbtb46. Alliance mouse Zbtb46 gene page
User Notes:	Additional information submitted by the research community Additional information submitted by the research community An investigator using mice with this allele reports when crossed to mice with floxed allele, at least 95% of the offspring of female Cre+ mice carry germline deletions. In contrast, less than 5% of the offspring of male Cre+ mice carry germline deletions.

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Zbtb46 Mutation:	36 strains or lines available

References

Original:	J:230708 Loschko J, et al., Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation. J Exp Med. 2016 Apr 4;213(4):517-34
All:	21 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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