Rbp4<tm1(RBP4)Zhel> Targeted Allele Detail MGI Mouse (MGI:5749289)

Rbp4^{tm1(RBP4)Zhel}
Targeted Allele Detail

Summary

Symbol:	Rbp4^{tm1(RBP4)Zhel}
Name:	retinol binding protein 4, plasma; targeted mutation 1, Zhenghua Li
MGI ID:	MGI:5749289
Synonyms:	hVal30:hRBP4, mRbp4^hRBP4
Gene:	Rbp4 Location: Chr19:38105077-38113729 bp, - strand Genetic Position: Chr19, 32.75 cM, cytoband D1
Alliance:	Rbp4^{tm1(RBP4)Zhel} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:220321
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:

Targeted (Humanized sequence, Inserted expressed sequence, RMCE-ready)

Mutation:

Insertion

Rbp4^{tm1(RBP4)Zhel} expresses 1 gene

Mutation details: ES cells containing the Rbp4^tm2Zhel null allele that serves as an acceptor in recombination mediated cassette exchange were electroporated with a replacement vector and a cre recombinase expression vector. The replacement vector consisted of a wild-type human RBP4 cDNA and a FRT-flanked puromycin resistance gene flanked by a loxKMR3 and a loxP site. (J:220321, J:260683)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Rbp4 Mutation:	21 strains or lines available

References

Original:	J:220321 Mu Y, et al., CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci. FEBS Lett. 2015 Mar 24;589(7):849-56
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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