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Flt4tm2.1(cre/ERT2)Sgo
Targeted Allele Detail
Summary
Symbol: Flt4tm2.1(cre/ERT2)Sgo
Name: FMS-like tyrosine kinase 4; targeted mutation 2.1, Sagrario Ortega
MGI ID: MGI:5750213
Synonyms: Vegfr3-CreERT2
Gene: Flt4  Location: Chr11:49500506-49543566 bp, + strand  Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
Alliance: Flt4tm2.1(cre/ERT2)Sgo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228184
Parent Cell Line:  v6.4 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Flt4tm2.1(cre/ERT2)Sgo expression driven by 1 gene
 
Mutation details: The targeting vector was constracted by inserting an IRES sequence and inducible cre recombinase gene fusion (cre/ERT2) into the 168 bs downstream of mouse Flt4 gene STOP codon on BAC RP23-445K3. Flp-mediate recombination removed the selection cassette. (J:228184, J:257380)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Flt4 (mouse)
Summary of all recombinase alleles driven by Flt4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flt4 Mutation:  77 strains or lines available
References
Original:  J:228184 Stanczuk L, et al., cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Rep. 2015 Mar 10;
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory