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Akap11tm1.2Jsco
Targeted Allele Detail
Summary
Symbol: Akap11tm1.2Jsco
Name: A kinase anchor protein 11; targeted mutation 1.2, John D Scott
MGI ID: MGI:5751858
Synonyms: AKAP220-KO
Gene: Akap11  Location: Chr14:78729686-78774248 bp, - strand  Genetic Position: Chr14, 41.46 cM
Alliance: Akap11tm1.2Jsco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234905
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A loxP site and FRT-flanked neomycin cassette are introduced into intron 5 followed by a loxP site placed in intron 7. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exons 6 and 7. Western blot anaylsis on nine tissues confirmed that no protein was expressed in mutant mice. (J:234905)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akap11 Mutation:  65 strains or lines available
References
Original:  J:234905 Whiting JL, et al., AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4328-37
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory