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Agrptm1.1(cre/EGFP)Stei
Targeted Allele Detail
Summary
Symbol: Agrptm1.1(cre/EGFP)Stei
Name: agouti related neuropeptide; targeted mutation 1.1, Robert A Steiner
MGI ID: MGI:5752370
Synonyms: Agrp-CreEGFP
Gene: Agrp  Location: Chr8:106293327-106306477 bp, - strand  Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
Alliance: Agrptm1.1(cre/EGFP)Stei page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221577
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Epitope tag, Recombinase, Reporter)
Mutation:    Insertion
 
Agrptm1.1(cre/EGFP)Stei expression driven by 1 gene
 
Mutation details: The targeting construct introduced upstream of the start codon a cre recombinase gene fused with EGFP (cre/EGFP), a myc tag, nuclear localization signal at the N-terminus and polyadenulation sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette introduced downstream of the fusion gene. (J:221577)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Agrp (mouse)
Summary of all recombinase alleles driven by Agrp.
 

Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agrp Mutation:  17 strains or lines available
References
Original:  J:221577 Sanz E, et al., Fertility-regulating Kiss1 neurons arise from hypothalamic POMC-expressing progenitors. J Neurosci. 2015 Apr 8;35(14):5549-56
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory