Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Aspmtm1(cre)Mrc
Name:	abnormal spindle microtubule assembly; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:5753079
Synonyms:	APSMdelta
Gene:	Aspm  Location: Chr1:139382510-139421829 bp, + strand  Genetic Position: Chr1, 61.45 cM, cytoband F
Alliance:	Aspmtm1(cre)Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:228026
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Aspmtm1(cre)Mrc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aspm (MGI:1334448)   Mutation details: The majority of exon 18 was replaced with an ires-cre cassette followed by a CAG-driven FRT-flanked neo gene via homologous recombination. The mutant protein lacks the terminal 1717 amino acids containing the calmodulin binding domain and the C-terminus. The deletion of a 2.6-kb genomic region of exon 18 yields a nonsense mutation resulting in a bicistronic mRNA product containing protein truncated at amino acid 1405, and ires-derived cre expression. Northern and Western blot analysis confirmed the predicted truncation of the mRNA and protein in homozygotes. (J:228026)

Activity:	Tissue activity of this recombinase allele
Driver:	Aspm (mouse) Summary of all recombinase alleles driven by Aspm. Alliance mouse Aspm gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aspm Mutation:	138 strains or lines available

Original:	J:228026 Capecchi MR, et al., ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 2015;6:8763
All:	1 reference(s)