Tg(Opalin-icre/ERT2)#Rjfl
Transgene Detail
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| Symbol: |
Tg(Opalin-icre/ERT2)#Rjfl |
| Name: |
transgene insertion, Robin JM Franklin |
| MGI ID: |
MGI:5763107 |
| Synonyms: |
Opalin-iCreERT2 |
| Transgene: |
Tg(Opalin-icre/ERT2)#Rjfl Location: unknown
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| Alliance: |
Tg(Opalin-icre/ERT2)#Rjfl page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Opalin-icre/ERT2)#Rjfl expression driven by
1 gene
Transgene expression driven by:
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Mutation details: The mouse was generated via bacterial artificial chromosome transgenesis using the Opalin genomic bacterial artificial chromosome RP24-510M10. Insertion of the iCreERT2-polyA-frt-Kanamycin-frt cassette was achieved by homologous recombination (with no loss of the genomic bacterial artificial chromosome) in BAC (RPCI24-510M10) immediately after the Opalin initiation codon ATG of the open reading frame of the Opalin sequence. The frt-kanamycin-frt was removed using flippase recombinase. Four founders were generated, three of which expressed the transgene. The one with highest expression was chosen for further experimentation. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:229987)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Opalin
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:229987 Crawford AH, et al., Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination. Am J Pathol. 2016 Mar;186(3):511-6 |
| All: |
3 reference(s) |
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Analysis Tools
