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Icosltm2Cdon
Targeted Allele Detail
Summary
Symbol: Icosltm2Cdon
Name: icos ligand; targeted mutation 2, Chen Dong
MGI ID: MGI:5763191
Synonyms: Icoslfl
Gene: Icosl  Location: Chr10:77904921-77915359 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Icosltm2Cdon page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86697
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation details: Two loxP sites were inserted so as to flank the two exons encoding the extracellular Ig-like domains as well as an FRT enclosed neomycin resistance gene. This allele was used to generate Icosltm1Cdon. (J:86697)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icosl Mutation:  28 strains or lines available
References
Original:  J:86697 Nurieva RI, et al., B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14163-8
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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