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Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu
Transgene Detail
Summary
Symbol: Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu
Name: transgene insertion 1, Sean Wu
MGI ID: MGI:5788432
Synonyms: Nkx2.5 enh-Cre
Transgene: Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu  Location: unknown  
Alliance: Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu page
Transgene
origin
Strain of Origin:  C57BL/6NCrl
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase, Reporter)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(Nkx2-5-tTA,tetO-EGFP/cre)1Smwu expression driven by 1 gene
 
Mutation details: The transgene was designed with (from 5' to 3') with a mouse NK2 homeobox 5 locus (Nkx2-5) promoter/enhancer sequence (2.1 kbp enhancer fragment from the regulatory region ~9.5 kbp upstream of the translation start site and the 0.5 kbp base promoter sequence), a Tet-Off cassette, an enhanced green fluorescent protein/Cre recombinase fusion gene sequence (eGFP/Cre) and a G-CSF polyA sequence. The Tet-Off cassette contains a tetracycline-regulated transactivator sequence (tTA), 2x polyA sequence and tetracycline-responsive element (TRE with minimal cytomegalovirus promoter CMVmin). (J:230304)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-5 (mouse)
Summary of all recombinase alleles driven by Nkx2-5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:230304 Chen WP, et al., Pharmacological inhibition of TGFbeta receptor improves Nkx2.5 cardiomyoblast-mediated regeneration. Cardiovasc Res. 2015 Jan 1;105(1):44-54
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory