Gdf5tm1.1(cre/ERT2)Eze
Targeted Allele Detail
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| Symbol: |
Gdf5tm1.1(cre/ERT2)Eze |
| Name: |
growth differentiation factor 5; targeted mutation 1.1, Elazar Zelzer |
| MGI ID: |
MGI:5789619 |
| Synonyms: |
Gdf5-CreER, Gdf5-CreERT2 |
| Gene: |
Gdf5 Location: Chr2:155782943-155787204 bp, - strand Genetic Position: Chr2, 77.26 cM
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| Alliance: |
Gdf5tm1.1(cre/ERT2)Eze page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:234264
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutations: |
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Insertion, Intergenic deletion
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Gdf5tm1.1(cre/ERT2)Eze expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Gdf5 (MGI:95688) |
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Mutation details: A targeting vector was designed to insert a Cre/ERT2 fusion gene, an SV40 polyA signal, and an frt-flanked neo-polyA cassette into the translation start site of Gdf5 gene. This construct was electroporated into C57BL/6-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with white C57BL/6J-congenic ROSA26::FLPe knock-in females to remove the neo selection cassette and to originate the colony.
(J:234264)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Gdf5
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gdf5 Mutation: |
32 strains or lines available
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| Original: |
J:234264 Shwartz Y, et al., Joint Development Involves a Continuous Influx of Gdf5-Positive Cells. Cell Rep. 2016 Jun 21;15(12):2577-87 |
| All: |
4 reference(s) |
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Analysis Tools
