Tg(Prnp-HTRA2*G399S)1Olri
Transgene Detail
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| Symbol: |
Tg(Prnp-HTRA2*G399S)1Olri |
| Name: |
transgene insertion 1, Olaf Riess |
| MGI ID: |
MGI:5790703 |
| Synonyms: |
Tg(Prnp-OMI*G399S)1OlRi |
| Transgene: |
Tg(Prnp-HTRA2*G399S)1Olri Location: unknown
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| Alliance: |
Tg(Prnp-HTRA2*G399S)1Olri page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prnp-HTRA2*G399S)1Olri expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
HTRA2 (27429) |
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Mutation details: The human cDNA containing the G399S mutation with a FLAG tag at the C-terminal is under the control of the mouse prion promoter. This line has a relative copy number of ~4. Mice express around five times the amount of endogenous RNA levels.
(J:229160)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:229160 Casadei N, et al., Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 Feb 1;25(3):459-71 |
| All: |
1 reference(s) |
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Analysis Tools
