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Bmp7tm1.1(cre/ERT2)Grsh
Targeted Allele Detail
Summary
Symbol: Bmp7tm1.1(cre/ERT2)Grsh
Name: bone morphogenetic protein 7; targeted mutation 1.1, Irina Grishina
MGI ID: MGI:5792123
Synonyms: Bmp7-CreERT2
Gene: Bmp7  Location: Chr2:172709805-172782114 bp, - strand  Genetic Position: Chr2, 95.54 cM
Alliance: Bmp7tm1.1(cre/ERT2)Grsh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Bmp7tm1.1(cre/ERT2)Grsh expression driven by 1 gene
 
Mutation details: A targeting construct was designed to replace exon 1, including the translation start, of the bone morphogenetic protein 7 (Bmp7) gene with a creER fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain). The Cre/ER sequence is followed by a hGHpA cassette (human Growth Hormone polyadenylation signal) and a frt-flanked puromycin resistance (puro) cassette. The chimeric mice were bred to mice expressing FLP Recombinase to remove puro cassette. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Bmp7 (mouse)
Summary of all recombinase alleles driven by Bmp7.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp7 Mutation:  37 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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