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Calb1tm2.1(cre)Hze
Targeted Allele Detail
Summary
Symbol: Calb1tm2.1(cre)Hze
Name: calbindin 1; targeted mutation 2.1, Hongkui Zeng
MGI ID: MGI:5792816
Synonyms: Calb1-IRES2-Cre-D, CBCre
Gene: Calb1  Location: Chr4:15881264-15906709 bp, + strand  Genetic Position: Chr4, 6.66 cM
Alliance: Calb1tm2.1(cre)Hze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146821
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Calb1tm2.1(cre)Hze expression driven by 1 gene
 
Mutation details: The targeting vector contains, from 5' to 3', an FRT3 site within Calb1 intron 10, a partial Calb1 exon 11 sequence up to and including the endogenous stop codon,an IRES2 sequence, Cre recombinase, a polyA sequence, an AttB site, a PGK-Neomycin cassette, an FRT5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 late polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequence (PGK-Neo-polyA::FRT5::RNA splice acceptor::3'hygro-polyA) and replaced it with the recombined AttB/AttP site (AttL). Mice have both endogenous gene and Cre recombinase expression directed to calbindin 1-expressing cells by the endogenous promoter/enhancer elements of the Calb1 locus. (J:146821)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Calb1 (mouse)
Summary of all recombinase alleles driven by Calb1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Calb1 Mutation:  28 strains or lines available
References
Original:  J:146821 Allen Institute for Brain Science, Cre transgenes and knockin alleles created at the Allen Insitute for Brain Science (AIBS). MGI Direct Data Submission. 2009-04-06;
All:  34 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory