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Trpm2tm1.1(icre)Jsmn
Targeted Allele Detail
Summary
Symbol: Trpm2tm1.1(icre)Jsmn
Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1.1, Jan Siemens
MGI ID: MGI:5795931
Synonyms: Trpm2-Cre
Gene: Trpm2  Location: Chr10:77743556-77805746 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance: Trpm2tm1.1(icre)Jsmn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235274
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Trpm2tm1.1(icre)Jsmn expression driven by 1 gene
 
Mutation details: A targeting vector containing a T2A viral 2A peptide, iCre recombinase sequence, T2A viral 2A peptide, multicistronic element (derived from insect Thosea asigna virus 2A), and FRT site flanked NEO cassette was inserted upstream of the Trpm2 gene stop codon. The resulting chimeric animals were crossed to FLPeR recombinase (Gt(ROSA)26Sor) expressing females to excise the FRT site flanked NEO cassette. (J:235274)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trpm2 (mouse)
Summary of all recombinase alleles driven by Trpm2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpm2 Mutation:  110 strains or lines available
References
Original:  J:235274 Song K, et al., The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Science. 2016 Sep 23;353(6306):1393-1398
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory