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Il2tm1.1(cre)Iwsh
Targeted Allele Detail
Summary
Symbol: Il2tm1.1(cre)Iwsh
Name: interleukin 2; targeted mutation 1.1, Makio Iwashima
MGI ID: MGI:5804692
Synonyms: il-2cre
Gene: Il2  Location: Chr3:37174862-37180103 bp, - strand  Genetic Position: Chr3, 18.3 cM, cytoband B-C
Alliance: Il2tm1.1(cre)Iwsh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:231266
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Il2tm1.1(cre)Iwsh expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert a cre recombinase cDNA, an frt-flanked neo cassette, and an internal ribosome entry site (IRES) into the Il2 gene just upstream of the first codon. The mice with correct targeted inserts were bred with Actin-FLPe females (on a C57BL/6 congenic background) to remove the neo selection cassette. (J:231266)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Il2 (mouse)
Summary of all recombinase alleles driven by Il2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il2 Mutation:  43 strains or lines available
References
Original:  J:231266 Yamamoto M, et al., Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013 Mar;61(3):831-41
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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