Ica1l<em1Jxia> Endonuclease-mediated Allele Detail MGI Mouse (MGI:5806150)

Ica1l^em1Jxia
Endonuclease-mediated Allele Detail

Summary

Symbol:	Ica1l^em1Jxia
Name:	islet cell autoantigen 1-like; endonuclease-mediated mutation 1, Jun Xia
MGI ID:	MGI:5806150
Gene:	Ica1l Location: Chr1:60024955-60082646 bp, - strand Genetic Position: Chr1, 30.45 cM, cytoband C2
Alliance:	Ica1l^em1Jxia page

Mutation
origin

Strain of Origin:

Mutation
description

Allele Type:		Endonuclease-mediated (Hypomorph)
Mutation:		Not Specified
		Mutation details: CRISPR/Cas technology targeted exon 2 to generate a knock-out allele lacking 23 nucleotides. Western blot analysis confirmed an 80% reduction in protein levels in the testes. (J:233657)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ica1l Mutation:	25 strains or lines available

References

Original:	J:233657 He J, et al., ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. J Cell Sci. 2015 Oct 15;128(20):3822-36
All:	1 reference(s)

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