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Rorbtm3.1(flpo)Hze
Targeted Allele Detail
Summary
Symbol: Rorbtm3.1(flpo)Hze
Name: RAR-related orphan receptor beta; targeted mutation 3.1, Hongkui Zeng
MGI ID: MGI:5806628
Synonyms: Rorb-IRES2-FlpO-D
Gene: Rorb  Location: Chr19:18907969-19088560 bp, - strand  Genetic Position: Chr19, 13.28 cM
Alliance: Rorbtm3.1(flpo)Hze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Rorbtm3.1(flpo)Hze expression driven by 1 gene
 
Mutation details: The targeting vector contains, from 5' to 3': a partial Rorb sequence spanning intron 9 (with an FRT3 site) through part of intron 10 up to and including the endogenous stop codon, an IRES2, a FlpO recombinase gene (a codon-optimized FLPe gene), a bovine growth hormone polyA sequence, an AttB site, a PGK-neo, an FRT5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequence and replaced it with the recombined AttB/AttP site (AttL). (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Rorb (mouse)
Summary of all recombinase alleles driven by Rorb.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rorb Mutation:  39 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory