Tmem135fun025
Chemically induced Allele Detail
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| Symbol: |
Tmem135fun025 |
| Name: |
transmembrane protein 135; fundus mutant 025 |
| MGI ID: |
MGI:5811600 |
| Gene: |
Tmem135 Location: Chr7:88788922-89053430 bp, - strand Genetic Position: Chr7, 49.32 cM, cytoband E1
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| Alliance: |
Tmem135fun025 page
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| Allele Type: |
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Chemically induced (ENU) (Not Specified) |
| Mutation: |
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Single point mutation
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Mutation details: This ENU-induced mutation was isolated in a screen for recessive vison phenotypes at Northwestern University Center for Functional Genomics. A point mutation, T>C, in the splice-donor site adjacent to exon 12 was identified, disrupting the splice donor site and resulting in skipping of exon 12 and a frame shift creating an early stop codon. The c-terminal region is shorter due to the stop codon and this mutation is predicted to abolish the 4th and 5th transmembrane helices and reverse the orientation of the remaining 3 transmembrane helices.
(J:237184)
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| Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tmem135 Mutation: |
55 strains or lines available
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| Original: |
J:237184 Lee WH, et al., Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Elife. 2016 Nov 15;5:e19264 |
| All: |
6 reference(s) |
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Analysis Tools
