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Gene Expression Data
Assay Details
Assay
Reference: J:141643 Montano MM, et al., Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 Feb 29;102(4):415-22
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5817410
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: anti-PECAM-1
Results
Specimen 4A whole mount WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: coronary artery Present Regionally restricted 4A (whole mount) WT Authors report expression in coronary arteries originating from the base of the ascending aorta with a regular branching pattern.
Specimen 4A whole mount HEXIM1 1-312: embryonic day 15.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS23: coronary artery Present Regionally restricted 4A (whole mount) HEXIM1 1-312 Expression in coronary arteries with a disorganized pattern of branching.
Specimen 4A section WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: coronary artery Present Regionally restricted 4A (section) WT Expression in coronary arteries in the epicardium.
Specimen 4A section HEXIM1 1-312: embryonic day 15.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS23: coronary artery Present Regionally restricted 4A (section) HEXIM1 1-312 Expression in an abundance of coronary vessels in the epicardium. Markedly decreased vascularization of the myocardium.
Specimen S1B PECAM1: embryonic day 17.5 (more )
Note: Double labeled: green - Pecam1; red - Hexim1 reporter (assay MGI:5817397)
Structure Level Pattern Image Note
TS25: endocardial lining Present Regionally restricted S1B overlay (lower) , S1B PECAM1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory