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Lefty1tm1(cre/Esr1*)Sia
Targeted Allele Detail
Summary
Symbol: Lefty1tm1(cre/Esr1*)Sia
Name: left right determination factor 1; targeted mutation 1, Shinich Aizawa
MGI ID: MGI:5817776
Synonyms: Lefty1CreERTM
Gene: Lefty1  Location: Chr1:180762587-180765965 bp, + strand  Genetic Position: Chr1, 84.46 cM, cytoband F
Alliance: Lefty1tm1(cre/Esr1*)Sia page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222398
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lefty1tm1(cre/Esr1*)Sia expression driven by 1 gene
 
Mutation details: The targeting vectors were constructed with the RP23-230B21 BAC clone. A CreERTM fusion protein carrying a polyA sequence and an FRT-flanked PGK-Neo cassette are inserted into the first exon of Lefty1 gene. (J:222398)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lefty1 (mouse)
Summary of all recombinase alleles driven by Lefty1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lefty1 Mutation:  41 strains or lines available
References
Original:  J:222398 Hoshino H, et al., AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression. Dev Biol. 2015 Jun 15;402(2):175-91
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory