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Nkx2-2tm1.1(icre)Aholz
Targeted Allele Detail
Summary
Symbol: Nkx2-2tm1.1(icre)Aholz
Name: NK2 homeobox 2; targeted mutation 1.1, Andreas Holz
MGI ID: MGI:5818053
Synonyms: Nkx2.2Cre-delta neo
Gene: Nkx2-2  Location: Chr2:147019466-147036163 bp, - strand  Genetic Position: Chr2, 72.63 cM, cytoband H
Alliance: Nkx2-2tm1.1(icre)Aholz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222414
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Nkx2-2tm1.1(icre)Aholz expression driven by 1 gene
 
Mutation details: The entire ORF of the Nkx2-2 gene including most of exon1, intron 1, and exon 2 is replaced by the codonimproved Cre-ORF and the polyA addition signal sequence (pA) followed by FRT-flanked neomycin selection cassette (PGK-neo) by homologous recomibination in ES cells. Chimeras were produced by ES cell injection into C57BL/6J blastocysts. The resulting line was bred with Flp deleter mice to remove the neo cassette. (J:222414)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-2 (mouse)
Summary of all recombinase alleles driven by Nkx2-2.
 

Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-2 Mutation:  14 strains or lines available
References
Original:  J:222414 Jarrar W, et al., Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system. Differentiation. 2015 Mar-Apr;89(3-4):70-6
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory