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Tnnt2tm1(cre/Esr1*)Ccai
Targeted Allele Detail
Summary
Symbol: Tnnt2tm1(cre/Esr1*)Ccai
Name: troponin T2, cardiac; targeted mutation 1, Chen-Leng Cai
MGI ID: MGI:5818273
Synonyms: Tnnt2MerCreMer-Neo
Gene: Tnnt2  Location: Chr1:135764092-135779998 bp, + strand  Genetic Position: Chr1, 59.32 cM
Alliance: Tnnt2tm1(cre/Esr1*)Ccai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224086
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tnnt2tm1(cre/Esr1*)Ccai expression driven by 1 gene
 
Mutation details: A cassette encoding cre recombinase fused to 2 mutated murine estrogen receptor ligand-binding domains (Mer; Esr1*) followed by FRT flanked neo selection cassette are inserted into the start codon of Tnnt2 locus with disruption of endogenous ATG by homologous recombination in ES cells. (J:224086)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tnnt2 (mouse)
Summary of all recombinase alleles driven by Tnnt2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnnt2 Mutation:  52 strains or lines available
References
Original:  J:224086 Yan J, et al., Generation of a tamoxifen inducible Tnnt2MerCreMer knock-in mouse model for cardiac studies. Genesis. 2015 Jun;53(6):377-86
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory