Tnnt2tm1.1(cre/Esr1*)Ccai
Targeted Allele Detail
|
|
| Symbol: |
Tnnt2tm1.1(cre/Esr1*)Ccai |
| Name: |
troponin T2, cardiac; targeted mutation 1.1, Chen-Leng Cai |
| MGI ID: |
MGI:5818274 |
| Synonyms: |
Tnnt2MCM, Tnnt2MerCreMer |
| Gene: |
Tnnt2 Location: Chr1:135764092-135779998 bp, + strand Genetic Position: Chr1, 59.32 cM
|
| Alliance: |
Tnnt2tm1.1(cre/Esr1*)Ccai page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:224086
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
Not Specified
|
|
| Allele Type: |
|
Targeted (Inducible, Null/knockout, Recombinase) |
| Inducer: |
|
tamoxifen |
| Mutation: |
|
Insertion
|
| |
|
Tnnt2tm1.1(cre/Esr1*)Ccai expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Tnnt2 (MGI:104597) |
|
|
| |
|
Mutation details: A cassette encoding cre recombinase fused to 2 mutated murine estrogen receptor ligand-binding domains (Mer; Esr1*) followed by FRT flanked neo selection cassette are inserted into the start codon of Tnnt2 locus, with disruption of endogenous ATG by homologous recombination in ES cells. Flp-mediated recombination removed the selection cassette, leaving a single FRT site behind.
(J:224086)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Tnnt2
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Tnnt2 Mutation: |
51 strains or lines available
|
|
| Original: |
J:224086 Yan J, et al., Generation of a tamoxifen inducible Tnnt2MerCreMer knock-in mouse model for cardiac studies. Genesis. 2015 Jun;53(6):377-86 |
| All: |
5 reference(s) |
|
Analysis Tools
