Kittm1(cre/Esr1*)Kkar
Targeted Allele Detail
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| Symbol: |
Kittm1(cre/Esr1*)Kkar |
| Name: |
KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Klaus Karjalainen |
| MGI ID: |
MGI:5818476 |
| Synonyms: |
KitMercreMer |
| Gene: |
Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
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| Alliance: |
Kittm1(cre/Esr1*)Kkar page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:233387
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
BALB/c
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Kittm1(cre/Esr1*)Kkar expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Kit (MGI:96677) |
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Mutation details: A codon-optimized IRES-MercreMer (MercreMer: cre recombinase fused to two modified estrogen receptor ligand binding domains at both ends) fused gene and a frt-flanked neomycin selection cassette were inserted into the 3' untranslated region (20 bp after the stop codon) of the Kit gene in embryonic stem cells by homologous recomibination.
(J:233387)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Kit
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Kit Mutation: |
182 strains or lines available
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| Original: |
J:233387 Sheng J, et al., Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells. Immunity. 2015 Aug 18;43(2):382-93 |
| All: |
8 reference(s) |
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Analysis Tools
