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Kittm3(cre/Esr1*)Ccai
Targeted Allele Detail
Summary
Symbol: Kittm3(cre/Esr1*)Ccai
Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 3, Chen-Leng Cai
MGI ID: MGI:5818527
Synonyms: c-kitMerCreMer-Neo
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Kittm3(cre/Esr1*)Ccai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227907
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Kittm3(cre/Esr1*)Ccai expression driven by 1 gene
 
Mutation details: A cassette encoding cre recombinase fused to 2 mutated murine estrogen receptor ligand-binding domains (Mer; Esr1*) followed by FRT flanked neo selection cassette are inserted into the start codon of kit locus with disruption of endogenous ATG by homologous recombination in ES cells. (J:227907)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Kit (mouse)
Summary of all recombinase alleles driven by Kit.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  182 strains or lines available
References
Original:  J:227907 Sultana N, et al., Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory