About   Help   FAQ
Kittm3(cre/Esr1*)Ccai
Targeted Allele Detail
Summary
Symbol: Kittm3(cre/Esr1*)Ccai
Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 3, Chen-Leng Cai
MGI ID: MGI:5818527
Synonyms: c-kitMerCreMer-Neo
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Kittm3(cre/Esr1*)Ccai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227907
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Kittm3(cre/Esr1*)Ccai expression driven by 1 gene
 
Mutation details: A cassette encoding cre recombinase fused to 2 mutated murine estrogen receptor ligand-binding domains (Mer; Esr1*) followed by FRT flanked neo selection cassette are inserted into the start codon of kit locus with disruption of endogenous ATG by homologous recombination in ES cells. (J:227907)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Kit (mouse)
Summary of all recombinase alleles driven by Kit.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  181 strains or lines available
References
Original:  J:227907 Sultana N, et al., Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory