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Htr2ctm1.1(cre)Heis
Targeted Allele Detail
Summary
Symbol: Htr2ctm1.1(cre)Heis
Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1.1, Lora Heisler
MGI ID: MGI:5819075
Synonyms: 5-HT2CRCRE
Gene: Htr2c  Location: ChrX:145745509-145980273 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Alliance: Htr2ctm1.1(cre)Heis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238329
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Htr2ctm1.1(cre)Heis expression driven by 1 gene
 
Mutation details: The targeting construct was generated by insertion of a FRT-NEO-FRT-IRES-CRE cassette between the stop codon and the polyA site of the gene. Homologous recomination in ES cells generated correctly targetted mice. Crossing resulting mice with FlpO deleter mice removed the selection cassette. (J:238329)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Htr2c (mouse)
Summary of all recombinase alleles driven by Htr2c.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:  13 strains or lines available
References
Original:  J:238329 Burke LK, et al., Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016 Mar;5(3):245-52
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory