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Gcgem1(cre/ERT2)Khk
Endonuclease-mediated Allele Detail
Summary
Symbol: Gcgem1(cre/ERT2)Khk
Name: glucagon; endonuclease-mediated mutation 1, Klaus H Kaestner
MGI ID: MGI:5825448
Synonyms: Gcg-CreERT2
Gene: Gcg  Location: Chr2:62304874-62313994 bp, - strand  Genetic Position: Chr2, 35.85 cM
Alliance: Gcgem1(cre/ERT2)Khk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, No functional change, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gcgem1(cre/ERT2)Khk expression driven by 1 gene
 
Mutation details: The allele is created using homologous recombination (aided by targeted CRISPR/cas9 endonuclease activity) to insert an IRES-Cre/ERT2 sequence into the 3' UTR of the gene. Cre expression is observed in pancreatic alpha cells and endocrine L cells. (J:94077, J:261359)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gcg (mouse)
Summary of all recombinase alleles driven by Gcg.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcg Mutation:  34 strains or lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
08/02/2024
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