Foxc2tm1.1(cre/ERT2)Rssr
Targeted Allele Detail
|
|
| Symbol: |
Foxc2tm1.1(cre/ERT2)Rssr |
| Name: |
forkhead box C2; targeted mutation 1.1, R Sathish Srinivasan |
| MGI ID: |
MGI:5829561 |
| Synonyms: |
Foxc2CreERT2 |
| Gene: |
Foxc2 Location: Chr8:121842910-121845634 bp, + strand Genetic Position: Chr8, 70.33 cM
|
| Alliance: |
Foxc2tm1.1(cre/ERT2)Rssr page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:228882
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
C57BL/6
|
|
| Allele Type: |
|
Targeted (Inducible, Null/knockout, Recombinase) |
| Inducer: |
|
tamoxifen |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Foxc2tm1.1(cre/ERT2)Rssr expression driven by
1 gene
Knock-in expression driven by:
|
| |
|
Mutation details: A targeting vector with a cDNA sequence encoding the CreER fusion gene, followed by a frt-flanked neomycin selection cassette replaced the open reading frame of the Foxc2 gene via homologouse recombination in C57BL/6-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts, and chimeric males were bred with C57BL/6 for germline transmission. At some point, they were bred with ROSA26::FLPe mice (on a C57BL/6J genetic background) for germline deletion of the neo selection cassette.
(J:228882)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Foxc2
(mouse)
|
| |
|
|
|
|
| Original: |
J:228882 Geng X, et al., Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016 Jan 1;409(1):218-33 |
| All: |
3 reference(s) |
|
Analysis Tools
